Amanda Rossi, McGill University Health Centre
Supervisor: Louise Pilote, McGill University Health Centre
Blood pRessure And Vascular hEalth around menopause (BRAVE) was one of the key projects of Theme 2 in the Vascular Network proposal and has now been amplified to include measures of cognitive impairment and novel methods of microvascular dysfunction detection. BRAVE is a cross-sectional study including pre- and postmenopausal women, conducted at the McGill University Health centre in Montreal.
Still 1 in 5 women sustain a stroke in her life. The risk of vascular events in women increases around menopause. Blood pressure (BP) variability would be as important as hypertension, if not more, in the prediction of vascular events, especially stroke. There is an urgent need to implement “primordial prevention” and slow down the progression of risk factors such as BP variability in menopausal women. There exists a knowledge gap about the determinants of BP variability, the so-called primordial causes. The risk factor profile of women around menopause is likely determined by biological and non-biological factors. Our study will help identify the sex and gender-related determinants of impaired BP patterns in pre- and postmenopausal women. Another important knowledge gap concerns the association of BP variability with the presence of microvascular dysfunction. The identification of novel vascular biomarkers associated with BP variability will help target preventive strategies for a broader category of sub-clinical diseases and related conditions such as microvascular dysfunction and possibly associated cognitive decline.