Cognitive Impairment Following Pre-eclampsia: Of Mice and Women
Dr. Louise Pilote, McGill University
Marilyn Cipolla, University of Vermont
We will use existing databases from a large cohort study, Coronary Artery Risk Development in Young Adults (CARDIA), to determine the impact of pre-eclampsia on cognitive function in women. These data will be acquired through the National Heart, Lung, and Blood Institute Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC). In leveraging this database, we can begin to explore the relationship between vascular complications in pregnancy and how these may impact cognitive function later in life which can eventually lead to more focused intervention studies in women. In collaboration with Dr. Hamel, and with expertise from Dr. Cipolla (University of Vermont), an animal study will be simultaneously undertaken to test whether a history of pre-eclampsia in female mice is associated with cognitive decline post-partum, in middle and in old age, and exploration of possible cerebrovascular and white matter disease biomarkers will be initiated.